Beta - Lactam and Fluoroquinolone Combination Antibiotic Therapy in Gram - 1 Negative Bacteremia 2 3
نویسندگان
چکیده
1 Department of Medicine, Division of Infectious Diseases, University of Kentucky, 8 Lexington, KY 2 Department of Medicine, Division of Infectious Diseases 3 Department 9 of Health Sciences Research, Division of Biomedical Statistics and Informatics, and 4 10 Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, 11 College of Medicine, Mayo Clinic, Rochester, MN 5 ; Research Center, King Fahd 12 Medical City, Riyadh, Saudi Arabia 13 14 Word count: 3837 15
منابع مشابه
Beta-lactam and fluoroquinolone combination antibiotic therapy for bacteremia caused by gram-negative bacilli.
The role of combination antibiotic therapy with a beta-lactam and a fluoroquinolone for bacteremia caused by gram-negative bacilli, to our knowledge, has not been previously described. Much of the previous study of combination therapy has included beta-lactams and aminoglycosides. We conducted a large retrospective cohort study to evaluate 28-day all-cause mortality in patients with monomicrobi...
متن کامل-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli
-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli Majdi N. Al-Hasan,* John W. Wilson, Brian D. Lahr, Kristine M. Thomsen, Jeanette E. Eckel-Passow, Emily A. Vetter, Imad M. Tleyjeh, and Larry M. Baddour Department of Medicine, Division of Infectious Diseases, University of Kentucky, Lexington, Kentucky; Department of Medicine, Division of ...
متن کاملMonotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study.
The aim of the present study was to test whether the combination of a beta-lactam drug plus an aminoglycoside has advantage over monotherapy for severe gram-negative infections. Of 2,124 patients with gram-negative bacteremia surveyed prospectively, 670 were given inappropriate empirical antibiotic treatment and the mortality rate in this group was 34%, whereas the mortality rate was 18% for 1,...
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3. Barza M, Ioannidis JP, Cappelleri JC, Lau J. Single or multiple daily doses of aminoglycosides: a meta-analysis. BMJ 1996; 312:338–45. 4. Leibovici L, Paul M, Poznanski O, et al. Monotherapy versus beta-lactam–aminoglycoside combination treatment for Gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother 1997; 41:1127–33. 5. Falagas ME. Monotherapy versus b...
متن کاملEmpiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis.
The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacteremia was analyzed. Among this cohort, 238 (31.3%) patients received inappropr...
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